ljdwefdsyrozcn | Дата: Воскресенье, 15.06.2014, 23:43 | Сообщение # 1 |
Группа: Гости
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tcsgroups | Дата: Среда, 04.03.2015, 13:07 | Сообщение # 2 |
Группа: Гости
| Docetaxel (as generic or under the trade specify Taxotere) is a clinically traditional anti-mitotic chemotherapy medication (medication which interferes with stall department). It is acclimated to in general payment the treatment of mamma, ovarian, prostate, and non-small cell lung cancer.<> - <> - <> - Docetaxel has an FDA approved allege as a service to treatment of patients who arrange locally advanced, or metastatic heart of hearts or non small-cell lung cancer who have undergone anthracycline-based chemotherapy and failed to put an end cancer advance or relapsed<> - and a European approval instead of exploit in hormone-refractory prostate cancer.<> - According to a 2005 article in the magazine Drugs, docetaxel administered as a one-hour infusion every three weeks commonly settled a ten return despatch, docetaxel is considered as or more compelling than doxorubicin, paclitaxel and fluorouracil as a cytotoxic agent.<> - Extent the effectiveness of docetaxel versus paclitaxel and other taxanes is still controversial. Diverse more brand-new articles have initiate "no confirmation that regimens containing docetaxel throw in the towel greater benefits than those including paclitaxel."<> - Additionally, the optimal scheduling of docetaxel and other taxanes remains unconfirmed. A three-week administration register old to be and is still considered operative but fashionable studies are indicating a weekly plan authority be better. A 2010 article in Accepted Clinical Pharmacology states, "weekly administration has emerged as the optimal schedule." Docetaxel is marketed worldwide comprised in the high regard Taxotere on Sanofi-Aventis.<> - Annual sales in 2010 were Euro 2.122 billion ($US 3.1 billion). The evident expired in 2010.<citation> Constitution Docetaxel is of the chemotherapy drug type; taxane, and is a semi-synthetic analogue of paclitaxel (Taxol), an extract from the bark of the rare Pacific yew tree Taxus brevifolia.<> - Apt to paucity of paclitaxel, vast study was carried out foremost to the formulation of docetaxel – an esterified artefact of 10-deacetyl baccatin III, which is extracted from the renewable and readily at one's disposal European yew tree. Docetaxel differs from paclitaxel at two positions in its chemical structure. It has a hydroxyl essential crowd on carbon 10, whereas paclitaxel has an acetate ester, and a tert-butyl carbamate ester exists on the phenylpropionate side sequence in place of of the benzyl amide in paclitaxel. The carbon 10 going sort change causes docetaxel to be more sea water soluble than paclitaxel.<> - Formulations and compositions Docetaxel is a white authority and is the active ingredient available in 20 mg and 80 mg Taxotere single-dose vials of concentrated anhydrous docetaxel in polysorbate 80.<> - <> - The solution is a discerning brown-yellow containing 40 mg docetaxel and 1040 mg polysorbate 80 per mL.<> - 20 mg Taxotere is distributed in a blister carton containing chestnut single-dose vial of Taxotere (docetaxel) preparation in 0.5 mL infecund pyrogen-free anhydrous polysorbate 80, and a only amount Taxotere solvent vial containing 1.5 mL 13% ethanol in saline to be combined and diluted in a 250 mL infusion bag containing 0.9% sodium chloride or 5% glucose after administration.<> - 80 mg Taxotere is supplied identically but with 2.0 mL polysorbate 80 and 6.0 mL 13% ethanol in saline. The docetaxel and solvent vials are combined to provide a solution of 10 mg/mL and the required dispense is drawn from this solution. Vials be suffering with an overfill to balance as a replacement for liquid harm during preparation, foaming, adhesion to vial walls and the uninteresting volume. 20 mg vials may be stored to 24 months here 25 °C away from insight and 80 mg vials respecting 26 months in the yet conditions.<> - Recently Sanofi has got approval in behalf of one-vial formulation.<citation>needed - With this one-vial formulation, the preparation of the infusion infusion is simplified nearby eliminating the blue ribbon dilution step. The two-vial and one-vial formulations restrict the same panacea substance, docetaxel trihydrate, and the but excipients (ethanol, polysorbate 80 and citric acid). The one-vial formulation is administered as an aqueous intravenous solution that contains the same tranquillizer nub in the same concentration as the already approved two-vial formulation. The unvarying form, quality, and volume of polysorbate 80 are closest in the infusion explication of both formulations. The only remainder between these two formulations is the sum of ethanol. From http://www.tcsindustry.com - TCS INDUSTRY LTD
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